反应 #4027

反应方程式

2-(p-methoxyphenyl)-5-octylpyridine

hydrobromic acid

water

→

2-(p-hydroxyphenyl)-5-octylpyridine

溶剂

acetic acid

反应条件

后处理

1. 1
   温度the solution was heated for 15 hours
2. 2
   温度under reflux
3. 3
   萃取the organic layer was extracted with chloroform
4. 4
   洗涤After washing the
5. 5
   萃取extract three times with water
6. 6
   其他the chloroform was removed by distillation
7. 7
   其他The residue was recrystallized from a mixture of acetone and hexane

实验过程

The 2-(p-methoxyphenyl)-5-octylpyridine was dissolved in 100 ml of acetic acid. 8 ml of 48% hydrobromic acid was added to the reaction solution and the solution was heated for 15 hours under reflux. 100 ml of water was added to the reaction solution and the organic layer was extracted with chloroform. After washing the extract three times with water, the chloroform was removed by distillation. The residue was recrystallized from a mixture of acetone and hexane to yield 8.3 g (0.029 mol) of 2-(p-hydroxyphenyl)-5-octylpyridine.

来源