反应 #4017

反应方程式

2-chloro-1,1,1-triethoxyethane

2-aminothiophenol

→

2-chloromethylbenzothiazole

收率 91.3%

溶剂

methylene chloride

反应条件

后处理

1. 1
   洗涤the resulting solution was washed with 3N HCl (10 ml)
2. 2
   其他The organic portion was evaporated
3. 3
   其他the residue chromatographed over silica gel

实验过程

A solution of 2-chloro-1,1,1-triethoxyethane (5.9 g) and 2-aminothiophenol (2.5 g) was heated at 80° C. for 15 minutes. After cooling to room temperature, it was dissovled in methylene chloride (30 ml) and the resulting solution was washed with 3N HCl (10 ml) and then with water (20 ml). The organic portion was evaporated and the residue chromatographed over silica gel to obtain 2-chloromethylbenzothiazole (3.35 g; 90% yield), m.p. 34° C.

来源