反应 #3940

反应方程式

1-bromo-3-chloropropane

1-(4-chlorobenzyl)homopiperazine

potassium hydroxide

→

1-(4-chlorobenzyl)-4-(3-chloropropyl)homopiperazine

收率 42.0%

溶剂

dimethyl sulfoxide

反应条件

后处理

1. 1
   其他an additional 30 minutes
2. 2
   其他at room temperature
3. 3
   萃取the product was extracted with ether
4. 4
   干燥the extract was dried (magnesium sulfate)
5. 5
   浓缩concentrated in vacuo
6. 6
   其他Final purification
7. 7
   其他the solvent was removed in vacuo

实验过程

15.7 g of 1-bromo-3-chloropropane were added to a cooled solution of 15.0 g of 1-(4-chlorobenzyl)homopiperazine and 12.0 g of potassium hydroxide in 50 ml of dimethyl sulfoxide. The mixture was stirred at 5°-10° C. for one hour, and then an additional 30 minutes at room temperature. After the addition of ice water, the product was extracted with ether, and the extract was dried (magnesium sulfate) and concentrated in vacuo. Final purification was effected on a silica gel column (methylene chloride:methanol, 9:1), and the solvent was removed in vacuo to give 8.4 g (42% of theory) of 1-(4-chlorobenzyl)-4-(3-chloropropyl)homopiperazine as an oil.

来源