反应 #3904

反应方程式

thiourea

sodium hydroxide

triethylamine

1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride

→

3-[4-(4-methylbenzyl)piperazin-1-yl]propanethiol dihydrochloride

收率 72.0%

溶剂

water

ethanol

反应条件

实验过程

The procedure described in Example 1(b) was followed, using 7.7 g of thiourea, 23.0 g of 1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride, 6.5 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 6.0 g of sodium hydroxide in 40 ml of water. Work-up, as described above, gave 16.4 g (72% of theory) of 3-[4-(4-methylbenzyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 273°-277° C. (dec.).

来源