反应 #3903

反应方程式

1-bromo-3-chloropropane

1-(4-methylbenzyl)piperazine

potassium hydroxide

dimethyl sulfoxide

→

1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride

溶剂

Water

反应条件

后处理

1. 1
   workup.STIRRINGthe mixture was stirred for an additional hour
2. 2
   萃取the product was extracted with ether
3. 3
   干燥the extract was dried (sodium sulfate)
4. 4
   workup.ADDITIONtreated with ethereal hydrochloric acid

实验过程

A mixture of 14.0 g of 1-(4-methylbenzyl)piperazine, 8.0 g of potassium hydroxide and 125 ml of dimethyl sulfoxide was stirred for 45 minutes. 11.8 g of 1-bromo-3-chloropropane were then added, and the mixture was stirred for an additional hour. Water was added, and the product was extracted with ether, and the extract was dried (sodium sulfate) and treated with ethereal hydrochloric acid to give 23.3 g (94% of theory) of 1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

来源