反应 #3880

反应方程式

title compound

t-butoxycarbonyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide

hydrogen chloride dioxane

→

title compound

N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide monohydrochloride

溶剂

dioxane

反应条件

后处理

1. 1
   浓缩After about 30 min. the solution was concentrated in vacuo to dryness
2. 2
   其他the residue triturated thoroughly with diethyl ether
3. 3
   其他The solid was collected
4. 4
   洗涤washed well with diethyl ether

实验过程

To a solution of the title compound of Example 2 (43.1 g, 0.11 mole) in 100 ml of dioxane was added 100 ml of 6M hydrogen chloride/dioxane. After about 30 min. the solution was concentrated in vacuo to dryness and the residue triturated thoroughly with diethyl ether. The solid was collected and washed well with diethyl ether, giving 34.7 g of the title compound, which was used in subsequent reactions without further purification.

来源