反应 #3871

反应方程式

1,3-dibromopropane

Potassium hydroxide

H2O

product

7-Hydroxy-3-piperidino-2,2-dimethylbenzofuran

→

desired product

7-(3-Bromopropoxy)-3-piperidino-2,2-dimethylbenzofuran

溶剂

diethyl ether

ether

反应条件

后处理

1. 1
   洗涤washed with 5% aq. HCl
2. 2
   洗涤The acidic solution is washed with ether
3. 3
   其他basified, affording an oil which
4. 4
   洗涤washed with sat'd NaCl
5. 5
   其他dried
6. 6
   过滤filtered
7. 7
   其他evaporated in vacuo

实验过程

Potassium hydroxide (1.47 g), tetrabutyl ammonium chloride (0.77 g) and H2O (1 ml) are added to a solution of the product obtained in Step 6. (6.6 g) in 1,3-dibromopropane (27 ml). The reaction mixture is stirred for 20 hours and diluted with diethyl ether and washed with 5% aq. HCl. The acidic solution is washed with ether and basified, affording an oil which is taken up in ether, washed with sat'd NaCl, dried, filtered and evaporated in vacuo affording the desired product as an oil.

来源