反应 #3864

反应方程式

potassium hydroxide

product

6-Hydroxy-4-piperidino-2,3-dihydrobenzopyran

1,3-dibromopropane

→

desired product

6-(3-Bromopropoxy)-4-piperidino-2,3-dihydrobenzopyran

溶剂

ether

diethyl ether

反应条件

后处理

1. 1
   洗涤washed with water
2. 2
   萃取extracted into 5% aq. HCl
3. 3
   洗涤The aqueous solution is washed with ether
4. 4
   其他yielding a yellow oil which
5. 5
   洗涤washed
6. 6
   其他dried
7. 7
   过滤filtered
8. 8
   其他evaporated

实验过程

Crushed potassium hydroxide (1.15 g) and tetrabutyl ammonium chloride (0.61 g) are added to a solution of the product obtained in Step 3. (4.8 g) in 1,3-dibromopropane (21 ml). The reaction mixture is stirred under nitrogen at RT for 48 hours, diluted with diethyl ether, washed with water and extracted into 5% aq. HCl. The aqueous solution is washed with ether and made alkaline yielding a yellow oil which is taken up in ether, washed, dried, filtered and evaporated to give the desired product as an oil.

来源