反应 #379

反应方程式

COC(=O)c1ccc(I)cc1O

CC(C)(C)OC(=O)N1CCNC

→

COC(=O)c1ccc(N2CCN(C

溶剂

COCCOC

反应条件

实验过程

tert-butyl piperazine-1-carboxylate (0.670 g, 3.60 mmol) and methyl 2-hydroxy-4-iodobenzoate (1 g, 3.60 mmol), BINAP (0.224 g, 0.36 mmol), cesium carbonate (2.461 g, 7.55 mmol) were put inDME (18 mL), tris(dibenzylideneacetone)dipalladium(0) (0.165 g, 0.18 mmol) was added last. Reaction wsa purged by nitrogen, and heated at90 °C overnight. No desired product was found.

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