反应 #3740

反应方程式

2-amino-2-cyanoacetamide

trimethylorthoformate

n-Propylamine

→

title compound

收率 61.1%

5-Amino-1-n-propylimidazole-4-carboxamide

收率 61.1%

溶剂

acetonitrile

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度under reflux for 0.75 hour
3. 3
   温度to cool
4. 4
   其他The solid which precipitated
5. 5
   过滤was collected by filtration
6. 6
   其他crystallised from methanol

实验过程

A mixture of 2-amino-2-cyanoacetamide (2.8 g, 0.0282 mol), trimethylorthoformate (3.4 g, 0.0321 mol) and acetonitrile (55 ml) was heated under reflux for 0.75 hour, then allowed to cool. n-Propylamine (1.8 g, 0.0305 mol) was then added dropwise, and the resulting mixture stirred at ambient temperature for 36 hours. The solid which precipitated was collected by filtration and crystallised from methanol to give the title compound as a colourless solid (2.9 g, 61%), m.p. 241°-243° C. Found: C,49.67; H,7.15; N,33.64. C7 H12N4O requires C,49.98; H,7.19; N,33.31%.

来源