反应 #3724

反应方程式

1,3-Di-n-butylxanthine

nitric acid

→

1,3-Di-n-butyl-8-nitro Xanthine

溶剂

acetic acid

反应条件

后处理

1. 1
   过滤the resulting yellow precipitate filtered off
2. 2
   洗涤washed with water (50 ml)
3. 3
   workup.DISSOLUTIONThe yellow crystals were dissolved in dichloromethane
4. 4
   洗涤washed twice with water
5. 5
   干燥The separated organic layer was then dried (anhydrous sodium sulphate)
6. 6
   浓缩concentrated
7. 7
   其他to give a crystalline product, yield 73 g (86%), m.pt 168° C.

实验过程

1,3-Di-n-butylxanthine (73 g, 0.28 mol) was dissolved in acetic acid (120 ml) and then treated with concentrated nitric acid (49 g) at 87° C. After 1 hour, the mixture was cooled to 5° C., the resulting yellow precipitate filtered off and washed with water (50 ml). The yellow crystals were dissolved in dichloromethane and washed twice with water. The separated organic layer was then dried (anhydrous sodium sulphate) and concentrated to give a crystalline product, yield 73 g (86%), m.pt 168° C.

来源