反应 #3714

反应方程式

(2RS,5RS)-2-dimethylaminomethyl-5-trifluoromethyl-cyclohexanone

3-trifluoromethyl-cyclohexanone

dimethylaminomethylene chloride

→

( 27 )

(1RS,2RS ,5RS)-3-(2-dimethylaminomethyl-1-hydroxy-5-trifluoromethyl-cyclohexyl)-phenol hydrochloride

溶剂

acetonitrile

反应条件

后处理

1. 1
   其他The 5-epimer (27) of compound (25) was prepared, under the conditions

实验过程

The 5-epimer (27) of compound (25) was prepared, under the conditions given in Example 27, from (2RS,5RS)-2-dimethylaminomethyl-5-trifluoromethyl-cyclohexanone, prepared from 3-trifluoromethyl-cyclohexanone and dimethylaminomethylene chloride in acetonitrile. (27) was obtained in a yield of 27% theoretical and had a melting point of 221°-223° C.

来源