反应 #367666

反应方程式

6-methoxynaphthoic acid

potassium carbonate

dimethyl sulfate

→

methyl 6-methoxynaphthoate

收率 90.9%

溶剂

acetone

acetone

反应条件

后处理

1. 1
   温度was heated to 50°-55° C. for 15 minutes
2. 2
   其他were then slowly dripped in over a period of 15 minutes
3. 3
   温度The mixture was then heated
4. 4
   温度at reflux for one hour

实验过程

A mixture of 9.1 g of 6-methoxynaphthoic acid and 7.2 g of anhydrous potassium carbonate in 45 ml of acetone was heated to 50°-55° C. for 15 minutes, and 4.5 ml of dimethyl sulfate were then slowly dripped in over a period of 15 minutes. The mixture was then heated at reflux for one hour and cooled to room temperature, after which all the acetone was stripped under vacuum. After workup, it was determined that the process resulted in the formation of 8.85 g of methyl 6-methoxynaphthoate having an HPLC purity of 83.3%.

来源