反应 #363925

反应方程式

2-(N-ethylanilino)ethanol

triethylamine

water

acetyl chloride

→

2-(N-ethylanilino)ethyl acetate

收率 99.9%

溶剂

acetone

反应条件

后处理

1. 1
   温度while cooling
2. 2
   萃取The organic layer was extracted with ethyl acetate
3. 3
   干燥dried with sodium sulfate
4. 4
   workup.DISTILLATIONThe solvent was then distilled off under reduced pressure

实验过程

51.8 g of 2-(N-ethylanilino)ethanol and 31.7 g of triethylamine were dissolved in 300 ml of acetone. To this was added slowly 25 g of acetyl chloride while cooling the resulting reaction solution with ice water. The resulting solution was then stirred for 6 hours at room temperature for reaction. 200 ml of water was then poured into the solution. The organic layer was extracted with ethyl acetate and dried with sodium sulfate. The solvent was then distilled off under reduced pressure to obtain 64.9 g of 2-(N-ethylanilino)ethyl acetate.

来源