反应 #362171

ord-0a2387611cff4e4db1aa4541ec381453

反应方程式

CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(C[N+]3(C)CCCC3)CS[C@H]12)c1csc(N)n1.Cl.O.O.[Cl-]
cefepime dihydrochloride dihydrate
NC(N)=NCCC[C@H](N)C(=O)O
L(+) arginine
→
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(C[N+]3(C)CCCC3)CS[C@H]12)c1csc(N)n1.Cl.NC(N)=NCCC[C@H](N)C(=O)O.O.O.[Cl-]
Cefepime Dihydrochloride Dihydrate L(+) Arginine

反应物

CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(C[N+]3(C)CCCC3)CS[C@H]12)c1csc(N)n1.Cl.O.O.[Cl-]
cefepime dihydrochloride dihydrate
NC(N)=NCCC[C@H](N)C(=O)O
L(+) arginine

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    workup.WAITblended for another 32 minutes

实验过程

Stable cefepime dihydrochloride dihydrate, 150 grams, and L(+) arginine, 86.25 g, were weighed and placed in a V-blender. The mixture was blended for 32 minutes. The blend was then screened through a 40 mesh US standard sieve, returned to the blender and blended for another 32 minutes.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US05391729uspto-grants-1995_02