反应 #362108

反应方程式

(3,4-methylenedioxyphenyl)acetic acid

cesium carbonate

methyl iodide

→

methyl (3,4-methylenedioxyphenyl)acetate

收率 87.6%

溶剂

DMF

DMF

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate
2. 2
   洗涤The organic phase was washed with saturated NaHCO3, water, brine
3. 3
   干燥dried (MgSO4)
4. 4
   过滤filtered
5. 5
   浓缩The filtrate was concentrated in vacuo

实验过程

A mixture of (3,4-methylenedioxyphenyl)acetic acid (4.64 g, 25.74 mmol) in dry DMF (40 mL), cesium carbonate (9.2 g, 25.74 mmol) and methyl iodide (3.7 g, 26.0 mmol) in dry DMF (40 mL) was stirred at room temperature for 3h. At the end of this period, the reaction mixture was poured into ice water and extracted with ethyl acetate. The organic phase was washed with saturated NaHCO3, water, brine and then dried (MgSO4) and filtered. The filtrate was concentrated in vacuo to provide pure methyl (3,4-methylenedioxyphenyl)acetate as an oil (4.38 g).

来源