反应 #356249

反应方程式

6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one

6-Cyclopropyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one

NaOH

hydroxylamine-O-sulfonic acid

hydroxylamine-O-sulfonic acid

NaOH

→

title compound

收率 64.0%

1-Amino-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one

收率 64.0%

溶剂

THF

H2O

反应条件

后处理

1. 1
   其他at 0° C
2. 2
   workup.ADDITIONAdded again at 0° C
3. 3
   萃取extracted with EtOAc
4. 4
   洗涤washed the organic layers with brine
5. 5
   干燥dried over Na2SO4
6. 6
   其他Removal of the solvent in vacuum
7. 7
   workup.WAITleft a residue (5.17 g) which
8. 8
   其他was purified by silica gel chromatography (400 g SiO2)

实验过程

To a solution of 6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (example C.28 step 2) (4.19 g, 15.0 mmol) in THF (225 mL) and 1M NaOH (90.0 mL, 90.0 mmol) was added dropwise a solution of hydroxylamine-O-sulfonic acid (HOSA) (95%, 5.36 g, 45.0 mmol) in H2O (60 mL) at 0° C. The reaction mixture was stirred at 23° C. for 20 h (76% conversion). Added again at 0° C. 3N NaOH (30 mL, 30.0 mmol) and then hydroxylamine-O-sulfonic acid (HOSA) (95%, 5.36 g, 45.0 mmol) and the reaction mixture was stirred at 23° C. for 3 days (88% conversion). Poured into ice water, extracted with EtOAc, washed the organic layers with brine, dried over Na2SO4. Removal of the solvent in vacuum left a residue (5.17 g) which was purified by silica gel chromatography (400 g SiO2) to give the title compound as a light yellow solid (2.81 g, 64%). MS (ISP) 295.5 [(M+H)+]; mp 132° C.

来源