反应 #3559

反应方程式

6-o-tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine

6-o-Tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

ammonia

→

title compound

1-(2-Amino-6-o-tolyl-pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl-urea

溶剂

methane

反应条件

后处理

1. 1
   其他The product was purified by MPLC
2. 2
   洗涤eluting with CHCl3 :EtOAc (1:1)
3. 3
   其他afford the pure product

实验过程

The title compound was prepared from 6-o-tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 90 and tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with CHCl3 :EtOAc (1:1) afford the pure product; mp 195°-197° C., CIMS (1% ammonia in methane): m/z (relative intensity) 351 (MH+ +1, 55), 352 (MH+ +2, 12), 84 (100).

来源