反应 #355790

反应方程式

1a

[1-(S)-(1-Benzyl-pyrrolidin-3-(R)-ylcarbamoyl)-2,2-dimethyl-propyl]-carbamic acid tert-butyl ester

→

2a

2-(S)-Amino-N-(1-benzyl-pyrrolidin-3-(R)-yl)-3,3-dimethyl-butyramide

溶剂

trifluoroacetic acid dichloromethane

反应条件

后处理

1. 1
   其他The solvent was removed by rotary evaporation
2. 2
   其他the resulting organic residue was carefully partitioned between dichloromethane
3. 3
   萃取The organic extract
4. 4
   干燥was dried over anhydrous sodium sufate
5. 5
   过滤filtered
6. 6
   浓缩concentrated

实验过程

A solution of 1a (0.80 g, 2.06 mmole) in 40% trifluoroacetic acid/dichloromethane (15 mL) was stirred at room temperature for 4 h. The solvent was removed by rotary evaporation, and the resulting organic residue was carefully partitioned between dichloromethane and a saturated solution of sodium bicarbonate (30 mL each). The organic extract was dried over anhydrous sodium sufate, filtered, and concentrated to give 2a as a light brown oil. This amine was used without further purification.

来源