反应 #355787

反应方程式

1-piperazin-1-yl-ethanone

N,N′-diisopropylethylamine

3-chloropropane chloroformate

→

title intermediate

4-acetylpiperazine-1-carboxylic acid 3-chloropropyl ester

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他evaporated in vacuo

实验过程

N,N′-diisopropylethylamine (0.10 mL, 6 mmol), followed by 3-chloropropane chloroformate (47.1 mg, 0.3 mmol) was added to a 5 mL glass vial containing 1-piperazin-1-yl-ethanone (38 mg, 0.3 mmol) dissolved in dichloromethane (1 mL). The reaction mixture was shaken at room temperature for about 0.5 h, then evaporated in vacuo to yield the title intermediate as an oily residue which was used without further treatment.

来源