反应 #355783

反应方程式

4-(methylthio)benzoic acid

N-[2-(dimethylamino)ethyl]-N′-ethylcarbodiimide hydrochloride

morpholine

→

title compound

4-{[4-(methylthio)phenyl]carbonyl}morpholine

溶剂

THF

反应条件

后处理

1. 1
   浓缩the reaction was concentrated in vacuo
2. 2
   其他the residue partitioned between ethyl acetate (100 mL) and 2M hydrochloric acid (150 mL)
3. 3
   其他The organic phase was separated
4. 4
   洗涤washed with 1M aqueous sodium carbonate solution
5. 5
   干燥dried over sodium sulfate
6. 6
   过滤filtered
7. 7
   浓缩concentrated in vacuo

实验过程

To a stirred solution of 4-(methylthio)benzoic acid (6.76 g, 40.2 mmol) and N-[2-(dimethylamino)ethyl]-N′-ethylcarbodiimide hydrochloride (9.24 g, 48.2 mmol) in THF (100 mL) was added morpholine (4.2 mL, 48.2 mmol). After stirring for 2 hours, the reaction was concentrated in vacuo and the residue partitioned between ethyl acetate (100 mL) and 2M hydrochloric acid (150 mL). The organic phase was separated, washed with 1M aqueous sodium carbonate solution, dried over sodium sulfate, filtered and concentrated in vacuo to give the title compound LC retention time 3.52 mins MS m/z 238 (MH+).

来源