反应 #355779

反应方程式

1-ethyl-1H-1,2,4-triazole-5-carbaldehyde

hydroxylamine hydrochloride

sodium bicarbonate

→

title compound

收率 31.1%

1-Ethyl-1H-1,2,4-triazole-5-carbaldehyde oxime

收率 31.1%

溶剂

ethanol

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度at reflux for 3 hours
3. 3
   温度After cooling
4. 4
   过滤the reaction was filtered
5. 5
   浓缩the filtrate concentrated in vacuo
6. 6
   其他The resulting residue was crystallised from ethanol

实验过程

A mixture of crude 1-ethyl-1H-1,2,4-triazole-5-carbaldehyde (17.7 g), hydroxylamine hydrochloride (12.7 g, 0.182 mol), sodium bicarbonate (15.3 g, 0.182 mol) and ethanol (60 mL) was heated at reflux for 3 hours. After cooling, the reaction was filtered and the filtrate concentrated in vacuo. The resulting residue was crystallised from ethanol to give the title compound (6.17 g) 1H-NMR (d6-DMSO) δ 1.32 (3H, t, J=7 Hz), 4.41 (2H, q, J=7 Hz), 8.02 (1H, s), 8.25 (1H, s), 12.70 (1H, s)

来源