反应 #355768

反应方程式

5-Acetyl-1-isopropyl-2,4-dimethylimidazole

DMA

→

title compound

收率 13.0%

5-(3-Dimethylaminoprop-2-en-1-oyl)-1-isopropyl-2,4-dimethylimidazole

收率 13.0%

溶剂

DMF

反应条件

后处理

1. 1
   温度under reflux, under an atmosphere of nitrogen, for 18 hours
2. 2
   其他The volatiles were evaporated in vacuo
3. 3
   其他The residue was purified by flash silica chromatography DCM

实验过程

5-Acetyl-1-isopropyl-2,4-dimethylimidazole (Method 8; 3g, 16.5 mmol) was dissolved in a mixture DMF.DMA (100 ml) and the mixture heated under reflux, under an atmosphere of nitrogen, for 18 hours. The volatiles were evaporated in vacuo. The residue was purified by flash silica chromatography DCM:MeOH (increasing in polarity from 100:0 to 95:5) to give the title compound (510 mg, 13%) as an orange oil. NMR 1.38 (d, 6H), 2.18 (s, 3H), 2.30 (s, 3H), 2.83 (s, 3H), 3.08 (s, 3H), 4.72 (q, 1H), 5.21 (d, 1H), 7.46 (d, 1H); m/z 236

来源