反应 #355744

反应方程式

5-fluoro-2-nitrotoluene

N-methylpyrrolidinone

5-amino-1-pentanol

K2CO3

→

5-(4-nitro-3-methylphenylamino)pentan-1-ol

收率 77.5%

溶剂

water

反应条件

后处理

1. 1
   温度after cooling to room temperature
2. 2
   其他The yellow precipitate formed
3. 3
   过滤was filtered off
4. 4
   干燥dried over P2O5

实验过程

2 g of 5-fluoro-2-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.6 g of 5-amino-1-pentanol and 2.14 g of K2CO3. The reaction medium was heated at 60° C. for 8 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 2.38 g of 5-(4-nitro-3-methylphenylamino)pentan-1-ol (17) were obtained.

来源