反应 #355732

反应方程式

2-chloromethyl-4-nitrophenol

methanol

sodium methoxide

→

expected product

2-methoxymethyl-4-nitrophenol

溶剂

water

反应条件

后处理

1. 1
   温度refluxed for 2 hours 30 minutes
2. 2
   温度the mixture was refluxed for another 30 minutes
3. 3
   温度The resulting mixture was cooled in an ice bath
4. 4
   其他the insoluble matter formed
5. 5
   过滤was filtered off
6. 6
   过滤The crystalline product was filtered off by suction
7. 7
   干燥dried over P2O5 at 40° C
8. 8
   其他11.4 g of crude products were isolated
9. 9
   其他recrystallized from 15 ml of isopropyl acetate

实验过程

18.7 g (0.1 mol) of 2-chloromethyl-4-nitrophenol and 50 ml of pure methanol were mixed together and refluxed for 2 hours 30 minutes. 37 ml of sodium methoxide (0.2 mol, 5.4 N solution in MeOH) were added and the mixture was refluxed for another 30 minutes. The resulting mixture was cooled in an ice bath and diluted with 350 ml of water, and the insoluble matter formed was filtered off. The filtrate was acidified with acetic acid (10 ml). The crystalline product was filtered off by suction, reslurried in ice-cold water and then dried over P2O5 at 40° C. 11.4 g of crude products were isolated and then recrystallized from 15 ml of isopropyl acetate to give 7.5 g of expected product.

来源