反应 #3555

反应方程式

6-(2,6-difluoro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

6-(2,6-Difluoro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

ammonia

→

title compound

1-[2-Amino-6-(2,6-difluoro-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea

溶剂

methane

反应条件

后处理

1. 1
   其他The product was purified by MPLC
2. 2
   洗涤eluting with a gradient of CHCl3 :EtOAc (1:1) to EtOAc
3. 3
   其他to afford the pure product

实验过程

The title compound was prepared from 0.25 g of 6-(2,6-difluoro-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 63 and 0.112 mL of tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with a gradient of CHCl3 :EtOAc (1:1) to EtOAc to afford the pure product; mp >300° C., CIMS (1% ammonia in methane): m/z (relative intensity) 373 (MH+ +1, 60), 374 (MH+ +2, 10), 274 (100).

来源