反应 #355118

反应方程式

2-amino-5-methylpyrazine

bromine

sodium hydroxide

sodium acetate trihydrate

→

2-Amino-3-bromo-5-methylpyrazine

溶剂

acetic acid

acetic acid

acetic acid

反应条件

后处理

1. 1
   其他at 2° C.
2. 2
   workup.ADDITIONpoured into ice
3. 3
   过滤filtered
4. 4
   萃取the residue extracted with ether
5. 5
   其他the 2-amino-3-bromo-5-methylpyrazine crystallized from a suitable solvent

实验过程

To acetic acid (1500 ml.), 2-amino-5-methylpyrazine (1 mole) and 326.5 g. sodium acetate trihydrate are slowly added 1.1 mole bromine in 180 ml. acetic acid at 2° C. in the absence of light. The mixture is stirred about 15 hours at 20° C., stripped of acetic acid in vacuo, poured into ice, made alkaline with sodium hydroxide, filtered, the residue extracted with ether, the extract stripped and the 2-amino-3-bromo-5-methylpyrazine crystallized from a suitable solvent.

来源