反应 #350615

反应方程式

trans-4-aminomethyl-1-cyclohexane carboxylic acid

benzyl chloroformate

→

trans-4-(N-carbobenzyloxy)aminomethyl-1-cyclohexane carboxylic acid

溶剂

NaOH

NaOH

反应条件

后处理

1. 1
   其他The cold bath was removed
2. 2
   workup.STIRRINGThe thick white paste was shaken with aqueous 1M HCl (100 mL)
3. 3
   其他the white solid was isolated by filtration
4. 4
   洗涤washed with H2O
5. 5
   其他dried overnight in vacuo

实验过程

To a 0° C. solution of trans-4-aminomethyl-1-cyclohexane carboxylic acid (6.28 g, 0.04 mol) in 10% aqueous NaOH (16 mL) was added dropwise benzyl chloroformate (8.29 g, 0.049 mol) and 10% aqueous NaOH (20 mL). The cold bath was removed and the reaction mixture was stirred vigorously for one hour. The thick white paste was shaken with aqueous 1M HCl (100 mL) and the white solid was isolated by filtration, washed with H2O, and dried overnight in vacuo to give trans-4-(N-carbobenzyloxy)aminomethyl-1-cyclohexane carboxylic acid.

来源