反应 #3502

反应方程式

water

potassium carbonate

chloromethylpropargyl ether

N-methoxybenzamide

→

N-methoxy-N-propargyloxymethylbenzamide

收率 91.9%

溶剂

acetonitrile

反应条件

后处理

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   萃取the mixture was extracted with ethyl acetate
3. 3
   其他The extract was dried
4. 4
   浓缩concentrated
5. 5
   其他purified by silica gel column chromatography

实验过程

0.6 g of N-methoxybenzamide was dissolved in 10 ml of acetonitrile, and 0.55 g of potassium carbonate and 0.42 g of chloromethylpropargyl ether were added thereto in this order. The mixture was stirred at room temperature for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.8 g of N-methoxy-N-propargyloxymethylbenzamide.

来源