反应 #3501

反应方程式

N-methoxy-2,4-dichlorobenzamide

potassium carbonate

propargyl bromide

N,N-dimethylformamide

→

propargyl N-methoxy-2,4-dichlorobenzimidate

收率 29.8%

溶剂

water

反应条件

后处理

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   萃取the mixture was extracted with ethyl acetate
3. 3
   其他The extract was dried
4. 4
   浓缩concentrated
5. 5
   其他purified by silica gel column chromatography

实验过程

1.0 g of N-methoxy-2,4-dichlorobenzamide, 0.75 g of potassium carbonate and 0.65 g of propargyl bromide were added to 10 ml of N,N-dimethylformamide, and the mixture was stirred for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.35 g of propargyl N-methoxy-2,4-dichlorobenzimidate.

来源