反应 #348456

反应方程式

o-toluoyl chloride

ammonia

3,5-dinitro-4-chloro-o-toluic acid

phosphorus pentachloride

→

3,5-dinitro-4-chloro-o-toluamide

溶剂

acetone

反应条件

实验过程

o-Toluoyl chlorides may be prepared by reacting 3,5-dinitro-4-chloro-o-toluic acid with phosphorus pentachloride. The resulting o-toluoyl chloride is then treated with ammonia in cold acetone to yield the corresponding 3,5-dinitro-4-chloro-o-toluamide which is converted to the corresponding nitrile by reaction with phosphorus pentoxide or preferably with POCl3.

来源