反应 #3478

反应方程式

1-[2-(tert-Butoxycarbonylamino)-5-methoxyphenyl]-2-butanone

→

2-ethyl-5-methoxy-1H-indole

收率 58.0%

溶剂

CH2Cl2

trifluoroacetic acid

反应条件

后处理

1. 1
   洗涤washed with water, NaHCO3 solution
2. 2
   其他the product chromatographed on silica (eluted with 20% EtOAc/hexane)

实验过程

1-[2-(tert-Butoxycarbonylamino)-5-methoxyphenyl]-2-butanone (7.33 g, 0.025 mol) in 120 mL of CH2Cl2 and 20 mL of trifluoroacetic acid was stirred for 20 hours, washed with water, NaHCO3 solution and the product chromatographed on silica (eluted with 20% EtOAc/hexane) to give 2.54 g (58% yield) of 2-ethyl-5-methoxy-1H-indole as a white solid, mp 49°-50° C.

来源