反应 #347386

反应方程式

GABA

cyclohexanol

Thionyl chloride

→

4-Aminobutanoic acid cyclohexyl ester hydrochloride

反应条件

后处理

1. 1
   温度The mixture was then refluxed for 4 hours
2. 2
   温度cooled
3. 3
   其他crystallized from ethyl ether
4. 4
   其他The white crystals obtained in this manner
5. 5
   过滤were filtered
6. 6
   其他dried

实验过程

GABA (8 g, 77.6 mmol) was suspended in 100 ml (0.96 mol) of cyclohexanol. Thionyl chloride (40 ml) was added dropwise to the mixture at 0° C. The mixture was then refluxed for 4 hours, cooled and crystallized from ethyl ether. The white crystals obtained in this manner were filtered and dried. NMR analysis confirmed the identity of the product.

来源