反应 #343921

反应方程式

2,3-dibromo-1-propene

phenylacetaldehyde

hydrochloric acid

→

2-bromo-5-phenyl-1-penten-4-ol

溶剂

toluene

反应条件

后处理

1. 1
   其他to react at the same temperature for 3 hours
2. 2
   过滤were filtered off
3. 3
   其他the resultant filtrate was separated
4. 4
   洗涤The organic phase was washed with a 7% sodium carbonate aqueous solution
5. 5
   workup.DISTILLATIONthe toluene was distilled off under reduced pressure
6. 6
   其他The resultant oily substance was purified by silica gel column chromatography

实验过程

49.93 Grams of 2,3-dibromo-1-propene were added dropwise to a mixture of 20.00 g of phenylacetaldehyde, 40 g of toluene, 60 g of 0.01% hydrochloric acid and 16.33 g of zinc powder at 30° C., and the mixture was allowed to react at the same temperature for 3 hours. After the reaction was completed zinc-derived insolubles were filtered off, and the resultant filtrate was separated. The organic phase was washed with a 7% sodium carbonate aqueous solution, and the toluene was distilled off under reduced pressure. The resultant oily substance was purified by silica gel column chromatography to give 24.01 g of 2-bromo-5-phenyl-1-penten-4-ol; nD25 =1.536, FI-MS m/e 240(M+), 242(M+2+).

来源