反应 #3423

反应方程式

n-BuLi

di-isopropylamine

7a-(6-Fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

hexachloroethane

→

title compound

收率 34.0%

7a-(5-chloro-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

收率 34.0%

溶剂

THF

反应条件

后处理

1. 1
   温度cooled to -78° C
2. 2
   温度The mixture was slowly warmed to room temperature
3. 3
   workup.STIRRINGstirred overnight
4. 4
   其他The reaction was quenched with 2N HCl
5. 5
   洗涤the mixture was washed with Et2O
6. 6
   萃取extracted with methylene chloride
7. 7
   其他dried
8. 8
   浓缩(MgSO4) and concentrated
9. 9
   其他The residue was chromatographed (silica gel; CHCl3 /MeOH, 99:1)

实验过程

n-BuLi (2.5M in hexanes, 0.232 mL, 0.58 mmol) was added to di-isopropylamine (0.077 mL, 0.58 mmol) in THF and stirred at room temperature for 15 minutes, then cooled to -78° C. 7a-(6-Fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine (115 mg, 0.56 mmol, from Example 12d) and hexachloroethane (400 mg, 1.7 mmol) were added. The mixture was slowly warmed to room temperature and stirred overnight. The reaction was quenched with 2N HCl, and the mixture was washed with Et2O. The aqueous layer was basified with 15% NaOH and extracted with methylene chloride. The organic extracts were combined, dried, (MgSO4) and concentrated. The residue was chromatographed (silica gel; CHCl3 /MeOH, 99:1) to afford the title compound as an oil (45 mg, 34%): 1H NMR (CDCl3, 300 MHz) δ1.60-1.72 (m, 2H), 1.80-2.06 (m, 6H), 2.64-2.72 (m, 2H), 3.14-3.27 (m, 2H), 8.00 (dd, J=8.8, 2.0 Hz, 1H), 8.15 (dd, J=2.0, 1.0 Hz, 1H); MS (CI/NH3) m/z: 241 (M+H)+.

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