反应 #342203

反应方程式

phthalic anhydride

4-aminobutyric acid

triethylamine

→

4-Phthalimidobutyric acid

溶剂

toluene

反应条件

后处理

1. 1
   温度The reaction mixture was heated
2. 2
   温度to reflux in a flask
3. 3
   其他equipped with a Dean Stark trap and condensor
4. 4
   温度After refluxing for 2.5 hours
5. 5
   温度the reaction solution was cooled in an ice bath which
6. 6
   其他resulted in the formation of a white precipitate
7. 7
   其他The solid was isolated by filtration
8. 8
   洗涤washed with 5% HCl (3×80 mL)

实验过程

To a mixture of phthalic anhydride (14.8 g, 100 mmole) and 4-aminobutyric acid (10.3 g, 100 mmole) in 150 mL of dry toluene was added triethylamine (1.3 mL, 9.3 mmole). The reaction mixture was heated to reflux in a flask equipped with a Dean Stark trap and condensor. After refluxing for 2.5 hours, the reaction solution was cooled in an ice bath which resulted in the formation of a white precipitate. The solid was isolated by filtration and washed with 5% HCl (3×80 mL) followed by cold water (2×70 mL). 4-Phthalimidobutyric acid was obtained as a white powder (16.8 g, 72%). m.p.: 118-118.6° C.

来源