反应 #341018

反应方程式

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

pyrrolidine-2(R)-carboxylic acid benzyl ester hydrochloride

sodium triacetoxyborohydride

→

desired product

收率 78.6%

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-2(R)-carboxylic acid benzyl ester

收率 78.6%

反应条件

后处理

1. 1
   其他Prepared

实验过程

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (75 mg. 0.223 mmol), pyrrolidine-2(R)-carboxylic acid benzyl ester hydrochloride (73 mg, 0.31 mmol) and sodium triacetoxyborohydride (71 mg, 0.335 mmol) to afford 92 mg (78%) of the desired product after purification.

来源