反应 #340950

反应方程式

water

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea

NCS

→

3-(5-Chloro-thiazol-2-yl)-1-cyclohexyl-1-piperidin-1-yl-urea

溶剂

DCM

DCM

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   干燥The organic phase was dried (MgSO4)
3. 3
   其他the solvent was removed in vacuo
4. 4
   workup.ADDITIONMeCN (1 mL) was added whereupon the product
5. 5
   其他precipitated
6. 6
   过滤The product was filtered off
7. 7
   其他dried

实验过程

1-Cyclohexyl-1-piperidin-1-yl-3-thiazol-2-yl-urea (50 mg, 0.16 mmol), prepared in an identical manner to Example 94 was dissolved in DCM (1 mL) and NCS (26 mg, 0.19 mmol)) was added. The reaction mixture was stirred for 3 days before DCM (20 mL) and water (20 mL) was added. The organic phase was dried (MgSO4) and the solvent was removed in vacuo. MeCN (1 mL) was added whereupon the product precipitated. The product was filtered off and dried. Yield: 20 mg.

来源