反应 #337975

反应方程式

oxazolidinone

(2R,5S)-5-Methyl-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one

diisopropylamine

oxazolidinone

(2R,5S)-2-Trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one

allyl bromide

→

oxazolidinone

收率 60.0%

(2R,5R)-5-Allyl-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one

收率 60.0%

反应条件

实验过程

(Wang et al. Synlett 1999, 1, 33) The reaction was carried out following a similar procedure to that described for the preparation of oxazolidinone 8 using n-butyllithium (1.31 M, 9.93 cm3, 13.0 mmol), diisopropylamine (1.82 cm3, 13.0 mmol), oxazolidinone 7 (2.10 g, 8.7 mmol) and allyl bromide (2.25 cm3, 26.0 mmol) to afford oxazolidinone 10 (1.48 g, 60%) as a light orange oil for which the NMR data were in agreement with the literature.

来源