反应 #337341

反应方程式

Sodium hydroxide

acetic acid 2-acetoxy-2-(5-ethyl-pyridin-2-yl)-ethyl ester

→

1-(5-ethyl-pyridin-2-yl)-ethan-1,2-diol

溶剂

water

反应条件

后处理

1. 1
   其他Reaction mixture
2. 2
   其他After completion of reaction
3. 3
   其他on TLC, reaction mixture
4. 4
   其他HCl and precipitated solid
5. 5
   过滤was filtered off
6. 6
   其他dried

实验过程

19.91 g (0.497 mol) Sodium hydroxide was added to a solution of 71 g (0.226 mol) acetic acid 2-acetoxy-2-(5-ethyl-pyridin-2-yl)-ethyl ester in 355 mL water. Reaction mixture was stirred at 40° C. for 2 hr. After completion of reaction on TLC, reaction mixture was neutralized with con. HCl and precipitated solid was filtered off and dried to get 1-(5-ethyl-pyridin-2-yl)-ethan-1,2-diol, Yield of the product was 32.1 g (68%).

来源