反应 #335194

反应方程式

product

3,4-Dihydroxy benzoic acid methyl ester

1-iodoheptane

potassium carbonate

→

desired product

收率 198.2%

3,4-Bis(heptyloxy)benzoic acid methyl ester

收率 198.2%

溶剂

2-butanone

反应条件

后处理

1. 1
   温度is heated
2. 2
   温度at reflux temperature for 44 hours
3. 3
   其他The cooled reaction mixture
4. 4
   过滤is filtered
5. 5
   浓缩concentrated in vacuo
6. 6
   其他The oily residue is purified by chromatography (silica gel: 10% ethyl acetate/hexane)

实验过程

A mixture of 25 g of product from Example 102, 72.3 g of 1-iodoheptane, 61.65 g of potassium carbonate and 500 ml of 2-butanone is heated at reflux temperature for 44 hours. The cooled reaction mixture is filtered and concentrated in vacuo. The oily residue is purified by chromatography (silica gel: 10% ethyl acetate/hexane) to give 53.7 g of the desired product.

来源