反应 #3315

反应方程式

ethylamine

4-chloro-2-methylthio-5-pyrimidinecarboxylate ethyl ester

triethylamine

→

4-ethylamino-2-methylthio-5-pyrimidinecarboxylate ethyl ester

收率 90.0%

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   浓缩concentrated in vacuo
2. 2
   其他partitioned between chloroform and saturated aqueous sodium bicarbonate
3. 3
   干燥The organic layer was dried over magnesium sulfate
4. 4
   过滤filtered
5. 5
   浓缩concentrated

实验过程

To a room temperature solution of 4-chloro-2-methylthio-5-pyrimidinecarboxylate ethyl ester (10.00 g, 43.10 mmol) in 150 mL of tetrahydrofuran was added triethylamine (18.5 mL, 133 mmol) followed by 9 mL of a 70% aqueous solution of ethylamine. The solution was stirred for 30 minutes, then concentrated in vacuo and partitioned between chloroform and saturated aqueous sodium bicarbonate. The organic layer was dried over magnesium sulfate, filtered, and concentrated to provide 9.32 g (90%) of 4-ethylamino-2-methylthio-5-pyrimidinecarboxylate ethyl ester as an oil.

来源