反应 #331462

反应方程式

2-bromopyridin-3-ol

1-bromo-2-fluoroethane

K2CO3

→

28

收率 68.0%

2-bromo-3-(2-fluoroethoxy)pyridine

收率 68.0%

溶剂

acetonitrile

反应条件

后处理

1. 1
   温度at refluxing for one day until TLC
2. 2
   过滤filter
3. 3
   其他dried
4. 4
   浓缩concentrated
5. 5
   其他The crude product was purified with column chromatography

实验过程

A mixture of 2-bromopyridin-3-ol 27 (0.1 mmol), 1-bromo-2-fluoroethane (0.2 mmol) and K2CO3 (0.4 mmol) in acetonitrile were stirred at refluxing for one day until TLC indicated that the reaction was complete, and then filter, dried and concentrated under reduce pressure. The crude product was purified with column chromatography to afforded 28 (yield, 68%). 1H NMR (CDCl3): δ 4.25-4.34 (m, 2H), 4.73-4.89 (m, 2H), 7.20-7.22 (m, 2H), 8.01 (s, 1H).

来源