反应 #326983

反应方程式

veratrylamine

1,4-butane sultone

→

3-[(3,4-dimethoxybenzyl)amino]-1-butanesulfonic acid

收率 18.0%

溶剂

1,4-dioxane

反应条件

后处理

1. 1
   温度The mixture was then heated
2. 2
   温度at reflux for 2 hours
3. 3
   过滤The solid was collected by filtration
4. 4
   洗涤washed with acetone (2×25 mL)
5. 5
   其他dried on pump

实验过程

To a solution of veratrylamine (1.50 g, 9.0 mmol) in 1,4-dioxane (8 mL) was added 1,4-butane sultone (1.21 g, 8.5 mmol) at room temperature. The mixture was then heated at reflux for 2 hours. The reaction was cooled to room temperature. The solid was collected by filtration, washed with acetone (2×25 mL) and dried on pump. Yield: 18%. 1H NMR (D2O, 500 MHz) δ 6.96 (m, 3H), 4.04 (s, 2H), 3.74 (m, 6H), 2.95 (t, 2H, J=6.8 Hz), 2.80 (t, 2H, J=7.3 Hz), 1.68, (m, 4H). 13C (D2O, 125 MHz) δ ppm 149.19, 148.50, 123.82, 123.36, 113.25, 112.17, 55.91, 50.88, 50.24, 46.41, 24.55, 21.50. ES-MS 302 (M−1).

来源