反应 #325834

反应方程式

1,1-dimethylethyl 4-(4-formyl-2-thiazolyl)-1-piperidinecarboxylate

hydrogen chloride

diethyl ether

→

title compound

2-(4-piperidinyl)-4-thiazolecarboxaldehyde mono-hydrochloride

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他evaporated under reduced pressure

实验过程

To a solution of 1,1-dimethylethyl 4-(4-formyl-2-thiazolyl)-1-piperidinecarboxylate (1.0 g, 3.4 mmol) in dichloromethane (20 mL) was added a solution of hydrogen chloride in diethyl ether (2.0 mL, 15 ml, 30 mmol). The reaction mixture was stirred under nitrogen at room temperature for 2 h and then evaporated under reduced pressure to give 1.2 g of the title compound as a white solid.

来源