反应 #325009

反应方程式

Ethyl iodide

3-oxo-pentanoic acid ethyl ester

NaOEt

→

title compound

收率 70.6%

2-Ethyl-3-oxo-pentanoic acid ethyl ester

收率 70.6%

溶剂

EtOH

反应条件

后处理

1. 1
   其他he reaction mixture
2. 2
   浓缩The reaction mixture was concentrated
3. 3
   洗涤eluted with 1-2% EtOAc/heptane

实验过程

To a solution of 3-oxo-pentanoic acid ethyl ester (5.19 g, 36 mmol) in anhydrous EtOH (40 mL) was added NaOEt (21% wt. in EtOH, 11.7 mL, 36 mmol). he reaction mixture was heated to 80° C. Ethyl iodide (6.18 g, 39.6 mmol) was added dropwise at 80° C. Stirring was continued at 80° C. for 16 hours. The reaction mixture was concentrated and loaded onto a silica gel column and eluted with 1-2% EtOAc/heptane to give 4.38 g of the title compound.

来源