反应 #324421

反应方程式

6-methoxy-1-naphthoic acid

thionyl chloride

→

6-methoxy-1-naphthoyl chloride

反应条件

后处理

1. 1
   温度the solution was heated
2. 2
   温度to reflux for 3 hours
3. 3
   浓缩the mixture was concentrated under reduced pressure

实验过程

Under an argon atmosphere, 6-methoxy-1-naphthoic acid (synthesized by the process of J. D. Moseley and J. P. Gilday, Tetrahedron, 62, 4690-4697 (2006)) (1.20 g, 5.93 mmol) was dissolved in thionyl chloride (5.00 mL, 68.8 mmol) and the solution was heated to reflux for 3 hours. After cooling to room temperature, the mixture was concentrated under reduced pressure to give the crude product of 6-methoxy-1-naphthoyl chloride (22) as a colorless oil. The product was used in the following reaction without further purification.

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