反应 #324417

反应方程式

2-(4-methoxyphenyl)propanoic acid

thionyl chloride

→

2-(4-methoxyphenyl)propanoyl chloride

反应条件

后处理

1. 1
   温度the solution was heated
2. 2
   温度to reflux for 27 hours
3. 3
   浓缩the mixture was concentrated under reduced pressure

实验过程

Under an argon atmosphere, 2-(4-methoxyphenyl)propanoic acid (synthesized by the process of I. Shiina, et al., Eur. J. Org. Chem., 5887-5890 (2008)) (1.20 g, 6.66 mmol) was dissolved in thionyl chloride (6.00 mL, 82.6 mmol) and the solution was heated to reflux for 27 hours. After cooling to room temperature, the mixture was concentrated under reduced pressure to give the crude product of 2-(4-methoxyphenyl)propanoyl chloride (16) as a colorless oil. The product was used in the following reaction without further purification.

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