反应 #324369

反应方程式

N-[3-(dimethylamino)propyl]methacrylamide

butanesultone

acetone

methanol

→

4-sulfonatobutyl[3-(methacryloylamino)propyl]dimethylammonium

收率 85.5%

溶剂

acetonitrile

反应条件

后处理

1. 1
   温度to cooling, to the reaction mixture
2. 2
   过滤The crystals deposited were collected by filtration
3. 3
   洗涤thoroughly washed with acetone

实验过程

In 380 ml of acetonitrile were dissolved 130 g (0.764 mol) of N-[3-(dimethylamino)propyl]methacrylamide, 104 g of butanesultone and 234 mg of 4-hydroxy-2,2,6,6-tetramethylpiperidinoxy and the solution was heated at 70° C. for 6 hours. After allowing to cooling, to the reaction mixture were added 1,350 ml of acetone and 150 ml of methanol and the mixture was stirred at room temperature for one hour. The crystals deposited were collected by filtration and thoroughly washed with acetone to obtain 200.0 g (yield: 85%) of 4-sulfonatobutyl[3-(methacryloylamino)propyl]dimethylammonium.

来源