反应 #324356

反应方程式

aniline

N,N-diisopropylethylamine

propane sultone

→

di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate

收率 94.0%

溶剂

acetonitrile

反应条件

后处理

1. 1
   其他The solvent was evaporated
2. 2
   workup.ADDITIONethylacetate was added
3. 3
   过滤The precipitated DIPEA bromide was filtered off
4. 4
   其他the filtrate was evaporated
5. 5
   workup.ADDITIONThe residue was treated with ether

实验过程

A mixture of aniline (7 mmol), N,N-diisopropylethylamine (DIPEA, 18 mmol) and propane sultone (16 mmol) was heated in a pressure tube in 10 mL of acetonitrile at 120-130° C. for 9 h under argon atmosphere. The solvent was evaporated and ethylacetate was added. The precipitated DIPEA bromide was filtered off and the filtrate was evaporated. The residue was treated with ether to give di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate as a white or pinky-white solid. Yield: 94%.

来源